“The cytochrome P450 could mean that other drugs taken with ibuprofen could stay in the body for a longer duration in males, and this has never been shown before,” Prof. Meanwhile, in female - but not in male - mice, the ibuprofen regimen increased the activity of some cytochrome P450s, a class of enzyme that contributes to the breakdown of drugs. When poorly regulated, hydrogen peroxide can damage proteins and apply stress to cells in the liver, affecting the organ’s health, the researchers explain. In the males’ livers, the researchers observed changes in at least 34 metabolic pathways, including those that help regulate some essential components of health: amino acids, hormones, vitamins, and the release of reactive oxygen and hydrogen peroxide within cells. The changes were different, depending on the sex of the mice. “We found that ibuprofen caused many more protein expression changes in the liver than we expected,” says study co-author Prof. ![]() The researchers used this method to assess the effects of the ibuprofen on the mice’s liver cells. The drug dosage was the equivalent of an adult human taking around 486 milligrams of ibuprofen per day.Īt the end of the week, the investigators used advanced mass spectrometry - a set of techniques that allow scientists to establish the ratio and type of chemicals present in a laboratory sample at any given time. To determine the true capacity of ibuprofen to cause liver problems, the researchers regularly administered moderate amounts of ibuprofen to mice for 1 week. As a result, medication can have unintended effects on the liver. The liver is the body’s key filter, processing elements of everything we ingest, including drugs. “The liver plays a key role in energy metabolism and is essential for whole-body homeostasis via the regulation of glucose, lipid, and amino acid metabolism,” the researchers explain in their study paper, which appears in Scientific Reports. One of them is liver damage, though this is rare.Īnd now, a new study in mice - from researchers at the University of California, Davis - suggests that ibuprofen’s adverse effect on liver health may be more significant than doctors suspect. Like any other drug, ibuprofen can have side effects. People tend to use it to relieve pain or the symptoms of a mild cold. and other countries, ibuprofen is readily available over the counter. In the United States, drugstores tend to sell the brand-name versions Motrin or Advil. ![]() Ibuprofen is a common nonsteroidal anti-inflammatory drug (NSAID). Share on Pinterest According to recent research in mice, ibuprofen may be more likely to damage the liver than doctors currently suspect.
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